Juan Ponce de Leon is thought to have accompanied Christopher Columbus on his voyage to the New World. He also explored present-day Puerto Rico and Florida coast. Francisco Vazquez de Coronado discovered the Grand Canyon and other famous landmarks in the American southwest. Hernando de Soto explored Florida and was the first to discover and cross the Mississippi River.
Juan Ponce de León explored Florida in 1513, Hernando de Soto traveled through the southeastern United States including crossing the Mississippi River between 1539 to 1542, and Francisco Vázquez de Coronado explored the southwestern U.S. from 1540 to 1542 looking for mythical cities of gold. Each played a significant role in expanding European understanding of the Americas during the Age of Exploration. Their expeditions had lasting impacts on both Native populations and European interests in the continent.
;