First used in 1821, the Santa Fe Trail was an important trade route that connected Missouri with Mexico.
First used in 1821, which of the following trade routes connected Missouri with Mexico? a. the California Trail b. the Oregon Trail c. the Santa Fe Trail d. the Wilderness Trail ;
The trade route that connected Missouri with Mexico, first used in 1821, is the Santa Fe Trail. It began in Independence, Missouri, and was significant for trade and commerce with Mexico. The correct answer is c. The Santa Fe Trail .
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