The correct answer for this question is A - the city in the United States that started out as a Spanish mission is Santa Fe. This is due to the fact that the Spanish were originally in that area, as well as Mexico, until the treaty was devised in which the Spanish gave up their claims in America.
The city that started as a Spanish mission in the United States is Santa Fe, founded in 1610 as part of Spain's efforts to expand and spread Christianity. It became a capital of the Kingdom of New Mexico and remains one of the oldest inhabited cities in America. Therefore, the correct option is A - Santa Fe.
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